TITLE: Transforming IgAN Management: A Clinical Guide to Diagnosis, Therapeutics, and Multidisciplinary Collaboration
 

Release Date: August 21, 2025

Expiration Date: August 21, 2026

STATEMENT OF NEED
Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide and a progressive autoimmune kidney disease associated with substantial morbidity, decreased quality of life, and long-term healthcare costs. Despite advances in understanding IgAN pathophysiology and the emergence of new targeted therapies, gaps remain in the timely recognition, diagnosis, and management of this condition. Early screening is critical to mitigating disease progression, yet surveys reveal that many primary care physicians and some nephrologists lack awareness of IgAN risk factors, diagnostic strategies, and evolving treatment options. Updated KDIGO guidelines introduce new pharmacologic therapies—including targeted-release budesonide, sparsentan, iptacopan, and others—requiring clinician education on evidence-based prescribing and monitoring. Additionally, nephrologists are well-positioned to serve as mentors and educators to the broader healthcare community to ensure consistent screening, timely referral, and co-management of patients with IgAN. Continuing medical education is essential to equip healthcare professionals with the latest clinical knowledge, improve diagnostic accuracy, optimize treatment approaches, and support interdisciplinary collaboration to improve patient outcomes.

EDUCATIONAL OBJECTIVES

DEVELOP strategies for screening in communities and clinical practice settings in order to correctly identify patients with IgAN during early stages of disease

INTEGRATE currently approved treatments in line with best practices, updated guidelines, and emerging data for patients with IgAN

ACTIVATE nephrologists to lead educational activities that increase PCP’s interest, knowledge and competency in screening, diagnosing, and referring patients with IgAN

TARGET AUDIENCE
Nephrologists, Nephrology APP’s, Primary Care Clinicians, Pharmacists involved in the care of patients with IgAN

FACULTY
 

Ellie Kelepouris, MD

Professor of Clinical Medicine
Interim Vice Chair for Clinical Affairs
Director of Outpatient Dialysis
Perelman School of Medicine
University of Pennsylvania
Renal Electrolyte Division
3400 Spruce Street
Renal Suite, 1 Founders
Philadelphia PA 19104

Abraham W. Aron, MD

Assistant Professor of Clinical Medicine
Georgetown University School of Medicine
MedStar Georgetown University Hospital

IGA Nephropathy Foundation Scientific Advisory Board
 

DISCLOSURE OF FINANCIAL RELATIONSHIPS
The “Policy on Identification, Mitigation, and Disclosure of Relevant Financial Relationships” of Albert Einstein College of Medicine-Montefiore Medical Center requires that any individual in control of content, including faculty, participating in CME activities disclose to the audience all relevant financial relationships with ineligible companies* in the past 24 months. Any individual in control of content who refuses to disclose, or whose disclosed relationships prove to create a conflict of interest, will be recused.

Individuals with the absence of relevant financial relationships with ineligible companies will be disclosed to the audience.

All financial relationships of individuals in a position to control the content of this CME activity are identified and mitigated prior to the educational activity.

*The ACCME defines an ineligible company as those whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.


ACCREDITED PROVIDER DISCLOSURE
The planners for this educational activity have disclosed no relevant financial relationship(s) with an ACCME-defined ineligible company in the last 24 months.

Faculty Disclosure(s)

FACULTY

Ellie Kelepouris, MD, discloses that she received consulting fees from Vera Pharmaceuticals and CSL Vifor for serving as a consultant, and served on advisory boards for Novartis and Boehringer Ingelheim; no compensation received.

Abraham W. Aron, MD, has no relevant financial relationships with an ACCME-defined ineligible company in the last 24 months.

CONTENT REVIEWER

Joel Neugarten, MD, has no relevant financial relationships with an ACCME-defined ineligible company in the last 24 months.

PROVIDERSHIP

This educational activity is jointly provided by Albert Einstein College of Medicine-Montefiore Medical Center and RealCME.  

ACCREDITATION STATEMENT

In support of improving patient care, this activity has been planned and implemented by Albert Einstein College of Medicine-Montefiore Medical Center and RealCME, LLC. Albert Einstein College of Medicine-Montefiore Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

CREDIT DESIGNATION STATEMENT
Albert Einstein College of Medicine-Montefiore Medical Center designates this other activity (blended live and enduring curriculum) for a maximum of 4.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
 

Other Credits

American Nurses Credentialing Center (ANCC) accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.
 

American Academy of Nurse Practitioners National Certification Program accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.
 

American Academy of Physician Assistants (AAPA) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society. Physician assistants may receive a maximum of 4.75 hours of Category 1 credit for completing this program.
 

American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) Program

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 4.75 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
 

DISCLOSURE OF UNLABELED USE
This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this CME activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a clinician relative to diagnostic and treatment options for a specific patient’s medical condition.
 

DISCLAIMER
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of Albert Einstein College of Medicine-Montefiore Medical Center, RealCME or Jazz Pharmaceuticals. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

METHOD OF PARTICIPATION/INSTRUCTIONS ON HOW TO RECEIVE CREDIT

Estimated time to complete this activity:  4 hours and 45 minutes

A total of 4.75 AMA PRA Category 1 Credits^TM  will be available to each participant:

To obtain credit, a score of 70% or better on the Final Assessment is required. This activity is offered at no cost to participants. Please proceed with the activity until you have successfully completed this curriculum, answered all test questions, completed the Final Assessment, Post Group Assessment, and evaluation, and have received a digital copy of your credit certificate.

• Baseline/Final Assessments: 30 minutes each for a total of up to 1.00 hour of CME 

• Three (3) Self-Study Modules: 15 minutes each for a total of up to 0.75 hour of CME 

• Two (2) Live Group Discussions: 45 minutes each for a total of up to 1.50 hour of CME 

• Two (2) Group Challenges: 30 minutes each for a total of up to 1.00 hour of CME 

• Action Plan (1) development: 30 minutes for a total of 0.50 hour of CME

If you are seeking credit, you must complete the assessment and evaluation at the conclusion of the activity. Your certificate can be printed immediately.

PRIVACY STATEMENT
Albert Einstein College of Medicine-Montefiore Medical Center, Center for Continuing Professional Development (Einstein-Montefiore) protects the privacy of personal and other information regarding participants and education collaborators. Einstein-Montefiore will not release personally identifiable information to a third party without the individual’s consent, except such information as is required for reporting to the ACCME. Einstein-Montefiore maintains physical, electronic, and procedural safeguards that comply with federal regulations to protect against the loss, misuse, or alteration of information collected from you.

COLLECTION AND USE OF YOUR PERSONAL INFORMATION
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing an activity. Required items include first name, last name, middle initial, degree, email address, address and phone number. These items are necessary. Participants are also required to complete an evaluation of each activity. All evaluative information submitted is collected, retained, and used by Einstein-Montefiore to continuously improve the learning experience. Einstein-Montefiore will not transfer, sell, or share personal information with outside parties or otherwise disclose personal information unless required to in a legal process. Einstein-Montefiore will retain your personal data only for the period necessary to accomplish the stated purposes and to comply with applicable laws.

CONTACT INFORMATION
For questions regarding CME credit, contact Albert Einstein College of Medicine-Montefiore Medical Center at cme@montefiore.org.

For technical questions related to this activity, please contact support@gathered.com.

GRANT PARTNER

The IGA Nephropathy Foundation collaborated with Einstein-Montefiore and RealCME, LLC, to develop this program.
 

ACKNOWLEDGEMENT OF FINANCIAL SUPPORT
This activity is supported by an educational grant from Otsuka America Pharmaceutical, Inc.