TITLE: The Evolving Landscape of GEP-NETs – From Precise Staging to Novel Treatments and Coordinated Care

ACKNOWLEDGEMENT OF FINANCIAL SUPPORT
This activity is supported by an educational grant from Exelixis and Novartis

Release Date: November 20, 2025

Expiration Date: November 20, 2026

STATEMENT OF NEED

The optimal management of Neuroendocrine Tumors (NETs) and Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs) presents significant challenges for healthcare professionals (HCPs) due to the diversity and complexity of these malignancies, leading to practice gaps in timely diagnosis and evidence-based therapeutic sequencing. Many clinicians struggle to recognize potential patients and apply best practices for diagnosis and surveillance. Furthermore, there is a limited understanding regarding the optimal use and sequencing of management strategies, including surgical approaches, systemic therapies like somatostatin analogues and Peptide Receptor Radionuclide Therapy (PRRT), and the effective integration of emerging novel treatments from the latest clinical trials.

This educational initiative is necessary to address these deficits by providing clear, evidence-based guidance on diagnosis, surveillance, and comprehensive treatment planning for NETs/GEP-NETs. By participating, HCPs will be equipped to identify diverse presentations, interpret the significance of functional vs. nonfunctional tumors, and apply current diagnostic guidelines. They will also learn to evaluate the roles of surgery and systemic therapies, understand the complex factors influencing treatment sequencing decisions (such as tumor characteristics, quality of life, and nutritional status), and appreciate the critical importance of the multidisciplinary care team in optimizing patient outcomes. Ultimately, this activity aims to ensure busy clinicians are up-to-date on novel agents and can develop strategies for their prompt and effective integration into clinical practice.

EDUCATIONAL OBJECTIVES

1. IDENTIFY the diverse clinical presentations and sites of origin of NETs/GEP-NETs to improve early diagnosis rates.
2. INTERPRET the importance of functional versus nonfunctional NETs in patient assessment and management plans.
3. APPLY the latest diagnostic guidelines and procedures for NETs/GEP-NETs   to enhance patient outcomes.
4. EVALUATE the role of surgery in managing NETs/GEP-NETs and the criteria for choosing between curative and palliative approaches.
5. ASSESS efficacy and sequencing of systemic therapies, including somatostatin analogues and PRRT, in the treatment plan for NETs.
6. EVALUATE factors influencing treatment sequencing decisions for NET/GEP-NETs, including tumor characteristics (grade, burden, progression rate), symptom management, previous treatment responses, patient preferences, QoL considerations, and nutritional status.
7. UNDERSTAND roles of various specialists (endocrinologists, oncologists, surgeons, radiologists, dieticians etc.) within the multidisciplinary team and the importance of collaboration in optimizing NETs/GEP-NETs management.
8. ANALYZE clinical trial data and evidence-based recommendations for emerging treatments in the management of patients with NETs/GEP-NETs.
9. DEVELOP strategies for the prompt and effective integration of novel therapies into treatment protocols for NETs/GEP-NETs.

TARGET AUDIENCE

Oncologists, endocrinologists, gastroenterologists, surgeons, radiologists, primary care physicians and other healthcare professionals involved in the multidisciplinary care of patients with neuroendocrine tumors.

FACULTY

	Chandrikha Chandrasekharan MBBS Clinical Associate Professor Division of GI Medical Oncology The University of Texas MD Anderson Cancer Center Houston, TX
Disclosure(s)	Chandrikha Chandrasekharan, MBBS, received honorarium for serving as a consultant from Tersera and Curium (these relationships have ended), and received honorarium for serving as on the advisory board and as a consultant fees from Exelixis.

CONTENT REVIEWER

John C. McAuliffe, M.D., Ph.D., F.A.C.S., F.S.S.O.
Attending Surgeon | Surgical Oncology 
Associate Professor in Surgery and Pathology | Albert Einstein College of Medicine
Surgeon Scientist | Tumor Microenvironment and Metastasis Program
Team Leader | Pancreatic Cancer | Integrated Imaging Program for Cancer Research
Bronx, NY 

John C. McAuliffe, MD, PhD, has no relevant financial relationships with ACCME-defined ineligible companies during the past 24 months.

PLANNERS

Steven Haimowitz, MD

RealCME

Steven Haimowitz, MD, has no relevant financial relationships with ACCME-defined ineligible companies during the past 24 months.

Erin Ash, MD

RealCME

Erin Ash, MD, has no relevant financial relationships with ACCME-defined ineligible companies during the past 24 months.

DISCLOSURE OF FINANCIAL RELATIONSHIPS
The “Policy on Identification, Mitigation, and Disclosure of Relevant Financial Relationships” of Albert Einstein College of Medicine-Montefiore Medical Center requires that any individual in control of content, including faculty, participating in CME activities disclose to the audience all relevant financial relationships with ineligible companies* in the past 24 months. Any individual in control of content who refuses to disclose, or whose disclosed relationships prove to create a conflict of interest, will be recused.

Individuals with the absence of relevant financial relationships with ineligible companies will be disclosed to the audience.

All financial relationships of individuals in a position to control the content of this CME activity are identified and mitigated prior to the educational activity.
 

*The ACCME defines an ineligible company as those whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.
 

PROVIDERSHIP

This educational activity is jointly provided by Albert Einstein College of Medicine-Montefiore Medical Center and RealCME.  

ACCREDITATION STATEMENT

In support of improving patient care, this activity has been planned and implemented by Albert Einstein College of Medicine-Montefiore Medical Center and RealCME, LLC. Albert Einstein College of Medicine-Montefiore Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

CREDIT DESIGNATION STATEMENT
Albert Einstein College of Medicine-Montefiore Medical Center designates this other/blended activity for a maximum of 5.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
 

Other Credits

American Nurses Credentialing Center (ANCC) accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.
 

American Academy of Nurse Practitioners National Certification Program accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.
 

American Academy of Physician Assistants (AAPA) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society. Physician assistants may receive a maximum of 5.00 AMA PRA Category 1 Credits™ for completing this program.

American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) Program

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 5.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
 

DISCLOSURE OF UNLABELED USE
This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this CME activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a clinician relative to diagnostic and treatment options for a specific patient’s medical condition.

DISCLAIMER
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of Albert Einstein College of Medicine-Montefiore Medical Center, RealCME, Exelixis or Novartis. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

 

METHOD OF PARTICIPATION/INSTRUCTIONS ON HOW TO RECEIVE CREDIT

Estimated time to complete this activity: 5.00 hours

To obtain credit, a score of 70% or better on the Final Assessment is required. This activity is offered at no cost to participants. Please proceed with the activity until you have successfully completed this curriculum, answered all test questions, completed the Final Assessment, Post Group Assessment, and evaluation, and have received a digital copy of your credit certificate.

• Baseline/Final Assessments: 30 minutes each for a total of up to 1.00 hour of CME
• Four (4) Self-Study Modules: 15 minutes each for a total of up to 1.00 hour of CME
• Two (2) Live Group Discussion: 45 minutes each for a total of up to 1.50 hour of CME
• Two (2) Group Challenges: 30 minutes each for a total of up to 1.00 hour of CME
• Action Plan (1) development: 30 minutes for a total of 0.50 hour of CME

If you are seeking credit, you must complete the assessment and evaluation at the conclusion of the activity. Your certificate can be printed immediately.

PRIVACY STATEMENT
Albert Einstein College of Medicine-Montefiore Medical Center, Center for Continuing Professional Development (Einstein-Montefiore) protects the privacy of personal and other information regarding participants and education collaborators. Einstein-Montefiore will not release personally identifiable information to a third party without the individual’s consent, except such information as is required for reporting to the ACCME. Einstein-Montefiore maintains physical, electronic, and procedural safeguards that comply with federal regulations to protect against the loss, misuse, or alteration of information collected from you.

COLLECTION AND USE OF YOUR PERSONAL INFORMATION
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing an activity. Required items include first name, last name, middle initial, degree, email address, address and phone number. These items are necessary. Participants are also required to complete an evaluation of each activity. All evaluative information submitted is collected, retained, and used by Einstein-Montefiore to continuously improve the learning experience. Einstein-Montefiore will not transfer, sell, or share personal information with outside parties or otherwise disclose personal information unless required to in a legal process. Einstein-Montefiore will retain your personal data only for the period necessary to accomplish the stated purposes and to comply with applicable laws.

CONTACT INFORMATION
For questions regarding CME credit, contact Albert Einstein College of Medicine-Montefiore Medical Center at cme@montefiore.org.
For technical questions related to this activity, please contact support@gathered.com.