TITLE: Navigating Real-World Issues in the Management of Eosinophilic Esophagitis
 

Release Date: October 10, 2025

Expiration Date:  October 10, 2026

STATEMENT OF NEED
EoE is gaining more attention, but it is still considered rare and often mistaken for other conditions. As a result, correct and timely diagnosis is challenging for clinicians. Many clinicians lack clarity on how to apply current EoE treatment algorithms, particularly regarding when and how to escalate to biologic therapy. As a result, patients may not meet payer requirements for prior treatment failure, which can delay or prevent access to dupilumab. Additionally, limited coordination between gastroenterologists, allergists, and support staff, combined with unclear roles for documentation, insurance submission, and follow-up, further restricts timely, effective treatment. These issues lead to delays, inconsistent care, and suboptimal patient outcomes.

EDUCATIONAL OBJECTIVES
 

1. APPLY diagnostic criteria and evaluation techniques to confirm EoE and support timely treatment access
2. INTEGRATE biologics into EoE treatment plans in alignment with current algorithms and payer requirements
3. OPTIMIZE multidisciplinary coordination and workflows to improve access to EoE therapies and reduce care fragmentation

TARGET AUDIENCE
Gastroenterologists, allergists/immunologists (MD, DO, APPs), primary care, pediatricians, and medical directors, pharmacy directors, and clinical pharmacists affiliated with MCOs, health systems, and other payer organizations.
 

FACULTY

Evan S. Dellon, MD, MPH

Professor of Medicine
Adjunct Professor of Epidemiology
Director, CGIBD Biostatistics and Clinical Research Core
Director, Center for Esophageal Diseases and Swallowing

Melanie A. Ruffner, MD, PhD

Assistant Professor of Pediatrics
University of Pennsylvania Perelman School of Medicine
Children’s Hospital of Philadelphia, Division of Allergy and Immunology

Hiva Pourarsalan, PharmD

Director of Pharmacy, Mercy Care Advantage

CONTENT REVIEWIER

Daniel S. Behin, MD
Assistant Professor of Medicine
Program Director, Gastroenterology Fellowship Program

Medical Director, Advanced Endoscopy Center
Albert Einstein College of Medicine – Montefiore Medical Center

DISCLOSURE OF FINANCIAL RELATIONSHIPS
The “Policy on Identification, Mitigation, and Disclosure of Relevant Financial Relationships” of Albert Einstein College of Medicine-Montefiore Medical Center requires that any individual in control of content, including faculty, participating in CME activities disclose to the audience all relevant financial relationships with ineligible companies* in the past 24 months. Any individual in control of content who refuses to disclose, or whose disclosed relationships prove to create a conflict of interest, will be recused.

Individuals with the absence of relevant financial relationships with ineligible companies will be disclosed to the audience.

All financial relationships of individuals in a position to control the content of this CME activity are identified and mitigated prior to the educational activity.
 

*The ACCME defines an ineligible company as those whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients.

Faculty Disclosures

Evan S. Dellon, MD, MPH, received research funding from Adare/Ellodi, Allakos, Arena/Pfizer, AstraZeneca, Celldex, Dr. Falk Pharma, Eupraxia, Ferring, GSK, Meritage, Miraca, Nutricia, Celgene/Receptos/BMS, Regeneron, Revolo, Sanofi, Shire/Takeda, Uniquity; received consulting fees for serving as a consultant from Abbvie, Adare/Ellodi, Alfasigma, ALK, Allakos, Amgen, Apogee, Apollo, Aqilion, Arena/Pfizer, AstraZeneca, Biocryst, Bryn, Calypso, Celgene/Receptos/BMS, Celldex, Domain, EsoCap, Eupraxia, Dr. Falk Pharma, Ferring, GI Reviewers, GSK, Holoclara, Invea, Knightpoint, LucidDx, Nexstone Immunology/Uniquity, Nutricia, Parexel/Calyx, Phathom, Regeneron, Revolo, Robarts/Alimentiv, Roivant, Sanofi, Shire/Takeda, Target RWE, Third Harmonic Bio, Upstream Bio; and received educational grants from Allakos, Aqilion, Holoclara, Invea.

Melanie A. Ruffner, MD, PhD, received research funding for serving as the Principal Investigator on post-market surveillance registry (real world use) of dupilumab from Regeneron/Sanofi; and received research funding for serving as a researcher from Beckman Coulter.

Hiva Pourarsalan, PharmD, has no relevant financial relationships with an ACCME-defined ineligible company in the last 24 months.

Daniel S. Behin, MD, has no relevant financial relationships with an ACCME-defined ineligible company in the last 24 months.

Although some of the disclosed relationships are directly related to the business lines and/or products discussed in the content, all faculty were thoroughly vetted and underwent training to ensure compliance with accreditation standards. Each faculty member completed a structured review and attestation process, which emphasized the importance of presenting scientifically balanced, evidence-based information that is free from commercial influence.

In addition, the planning committee carefully reviewed presentations and educational materials prior to the activity to confirm alignment with best practices for independence and objectivity. Ongoing monitoring during the activity also ensured that any potential conflicts were appropriately managed. These measures collectively provided safeguards against bias and upheld the integrity of the educational content.

PROVIDERSHIP

This educational activity is jointly provided by Albert Einstein College of Medicine-Montefiore Medical Center and RealCME.  

ACCREDITATION STATEMENT

In support of improving patient care, this activity has been planned and implemented by Albert Einstein College of Medicine-Montefiore Medical Center and RealCME, LLC. Albert Einstein College of Medicine-Montefiore Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


CREDIT DESIGNATION STATEMENT
Albert Einstein College of Medicine-Montefiore Medical Center designates this other activity (blended live and enduring curriculum) for a maximum of 5.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
 

Other Credits

American Nurses Credentialing Center (ANCC) accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.
 

American Academy of Nurse Practitioners National Certification Program accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.
 

American Academy of Physician Assistants (AAPA) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society. Physician assistants may receive a maximum of 5.00 hours of Category 1 credit for completing this program.
 

American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) Program

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 5.00 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
 

DISCLOSURE OF UNLABELED USE
This activity may or may not discuss investigational, unapproved, or off-label use of drugs. Participants are advised to consult prescribing information for any products discussed. The information provided in this CME activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a clinician relative to diagnostic and treatment options for a specific patient’s medical condition.

DISCLAIMER
The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of Albert Einstein College of Medicine-Montefiore Medical Center, RealCME or Jazz Pharmaceuticals. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.
 

METHOD OF PARTICIPATION/INSTRUCTIONS ON HOW TO RECEIVE CREDIT

Estimated time to complete this activity:  5 hours

To obtain credit, a score of 70% or better on the Final Assessment is required. This activity is offered at no cost to participants. Please proceed with the activity until you have successfully completed this curriculum, answered all test questions, completed the Final Assessment, Post Group Assessment, and evaluation, and have received a digital copy of your credit certificate.

A total of 5.00 AMA PRA Category 1 Credits™ will be available to each participant 

• Baseline/Final Assessments: 30 minutes each for a total of up to 1.00 hour of CME 
• Four (4) Self-Study Modules: approximately 15 minutes each for a total of up to 1.00 hour of CME 
• Two (2) Live Group Discussions: 45 minutes each for a total of up to 1.50 hour of CME 
• Two Group Challenges (2): 30 minutes each for a total of up to 1.00 hour of CME 
• Action Plan (1) development: 30 minutes for a total of 0.50 hour of CME 

If you are seeking credit, you must complete the assessment and evaluation at the conclusion of the activity. Your certificate can be printed immediately.

PRIVACY STATEMENT
Albert Einstein College of Medicine-Montefiore Medical Center, Center for Continuing Professional Development (Einstein-Montefiore) protects the privacy of personal and other information regarding participants and education collaborators. Einstein-Montefiore will not release personally identifiable information to a third party without the individual’s consent, except such information as is required for reporting to the ACCME. Einstein-Montefiore maintains physical, electronic, and procedural safeguards that comply with federal regulations to protect against the loss, misuse, or alteration of information collected from you.


COLLECTION AND USE OF YOUR PERSONAL INFORMATION
The submission of certain personally identifiable information is necessary to award and track the credits participants may earn after completing an activity. Required items include first name, last name, middle initial, degree, email address, address and phone number. These items are necessary. Participants are also required to complete an evaluation of each activity. All evaluative information submitted is collected, retained, and used by Einstein-Montefiore to continuously improve the learning experience. Einstein-Montefiore will not transfer, sell, or share personal information with outside parties or otherwise disclose personal information unless required to in a legal process. Einstein-Montefiore will retain your personal data only for the period necessary to accomplish the stated purposes and to comply with applicable laws.


CONTACT INFORMATION
For questions regarding CME credit, contact Albert Einstein College of Medicine-Montefiore Medical Center at cme@montefiore.org.

For technical questions related to this activity, please contact support@gathered.com.

ACKNOWLEDGEMENT OF FINANCIAL SUPPORT
This activity is supported by an educational grant from Regeneron Pharmaceuticals, Inc.